The San Francisco 49ers (1-0) are listed as touchdown favorites when they visit the Los Angeles Rams (1-0) in an NFC West matchup on Sunday, September 17, 2023 at SoFi Stadium. The point total is set at 45 points for the outing.

Before the 49ers play the Rams, prepare for the matchup by taking a look at their recent betting trends and insights. Before the Rams meet the 49ers, check out their betting insights and trends.

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Rams vs. 49ers Odds, Spread, Over/Under

Here's a look at the odds, spread and over/under for this matchup at several sportsbooks.

Favorite Total San Francisco Moneyline Los Angeles Moneyline
BetMGM 49ers (-7) 45 -350 +260 Bet on this game with BetMGM
FanDuel 49ers (-7) 45.5 -330 +265 Bet on this game with FanDuel

Other Week 2 Odds

Los Angeles vs. San Francisco Game Info

  • When: Sunday, September 17, 2023 at 4:05 PM ET
  • Where: SoFi Stadium in Inglewood, California
  • TV Info: FOX
  • Live Stream: Watch this game on Fubo!

Rams vs. 49ers Betting Insights

  • Los Angeles beat the spread six times in 17 games last season.
  • The Rams were an underdog by 7 points or more last year twice, and failed to cover both times.
  • There were six Los Angeles games (out of 17) that went over the total last year.
  • San Francisco covered the spread 11 times in 17 games last season.
  • The 49ers' ATS record as 7-point favorites or more was 5-2 last year.
  • San Francisco had nine of its 17 games go over the point total last season.

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