According to our computer model, the San Francisco 49ers will beat the Los Angeles Rams when they play at SoFi Stadium on Sunday, September 17 (at 4:05 PM ET). We have more projections, regarding the point spread, total and final score, available in this article.

The 49ers made things happen on both sides of the ball last season, as they ranked fifth-best in total offense (365.6 yards per game) and best in total defense (300.6 yards allowed per game). The Rams ranked worst in total offense (280.5 yards per game) last season, but they played slightly better on defense, ranking 19th with 341.1 yards allowed per contest.

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Rams vs. 49ers Predictions and Picks

ATS Over/Under Score Prediction
Toss Up (Spread: 49ers by 7) Under (45.5) 49ers 24, Rams 16

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Rams Betting Info

  • The moneyline for this contest implies a 27.8% chance of a victory for the Rams.
  • Los Angeles went 6-10-1 ATS last year.
  • The Rams were an underdog by 7 points or more last year twice, and failed to cover both times.
  • Los Angeles and its opponent combined to go over the point total six out of 17 times last season.
  • Rams games averaged 42.3 total points last season, 3.2 fewer than the total for this matchup.

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49ers Betting Info

  • The 49ers have a 77.8% chance to win this contest based on the moneyline's implied probability.
  • San Francisco compiled an 11-6-0 ATS record last year.
  • The 49ers were favored by 7 points or more seven times last season, and covered the spread in five of those matchups.
  • Last season, nine San Francisco games went over the point total.
  • 49ers games last season posted an average total of 42.2, which is 3.3 points fewer than the total for this matchup.

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Rams vs. 49ers 2022 Scoring Insights

Pts Pts Allowed Home Pts Home Pts Allowed Away Pts Away Pts Allowed
San Francisco 26.5 16.3 28 14.8 24.8 18
Los Angeles 18.1 22.6 21.9 22.8 13.8 22.4

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