The San Francisco 49ers (1-0) take on a fellow NFC West foe when they visit the Los Angeles Rams (1-0) on Sunday, September 17, 2023 at SoFi Stadium, and if you're looking for best bets, we have them.

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When is 49ers vs. Rams?

  • Game Date: Sunday, September 17, 2023
  • Time: 4:05 PM ET
  • TV: FOX
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Watch the NFL live all season long with Fubo!

Best Moneyline Bet

  • Prediction: San Francisco 24 - Los Angeles 16
  • The 49ers have a 76.5% chance to win this contest, based on the implied probability of the moneyline.
  • The 49ers were the moneyline favorite 16 total times last season. They finished 13-3 in those games.
  • San Francisco won all six games it played as a moneyline favorite with odds of -325 or shorter.
  • Last season, the Rams were the underdog 12 times and won two of those games.
  • Last season, Los Angeles was at least a +260 underdog on the moneyline two times, losing each of those contests.

Who will win? The 49ers or Rams? Head to BetMGM and make your pick!

Against the Spread Pick

  • Pick ATS: Los Angeles (+7.5)
  • The 49ers were 11-6-0 against the spread last season.
  • As 7.5-point or greater favorites last season, San Francisco went 5-2.
  • The Rams had six wins in 17 games against the spread last year.
  • Los Angeles was winless ATS (0-1-1) when playing as at least 7.5-point underdogs last season.

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Best Over/Under Pick

  • Pick OU: Under (45)
  • These teams averaged a combined 44.6 points per game a season ago, 0.4 fewer points than the total of 45 set for this matchup.
  • Opponents of the two teams averaged a combined 6.1 less points per game (38.9) last season than this game's over/under of 45 points.
  • Last season, nine of the 49ers' games went over the point total.
  • The Rams and their opponent combined to go over the point total seven out of 17 times last season.

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