The accident happened in the east bound lanes of the freeway near the H-3 off ramp just before midnight.
Police say the car was traveling at a high rate of speed, hit the median then, flipped over and came to its final stop on its roof.
The driver of the car, a 19 year old man, is in critical condition at the Queens Medical Center.
All of the East bound lanes on Moanalua freeway were shut down to traffic. And three lanes going west were also closed due to debri from the crash.