Police say a Nissan was driving east bound on Farrington Highway when the crash happened just before 1 a.m.
According to reports the Sport Utility Vehicle was speeding and passing cars.
"The vehicle lost control, went onto the side walk, off onto the gravel shoulder and into a tree," Sgt. John Agno said.
The driver of the SUV and one of the passengers were taken to Queen's Medical Center in serious condition.
A second passenger was extricated from the vehicle, and taken to Queen's Medical Center in critical condition.
Police say that passenger died a few hours later.
Officers say all three victims are men in their 30's.