EMS Chief Patricia Dukes said the new facility will be home base for units that were based at Straub Hospital and Kuakini Medical Center.
"This is a residential community and having two ambulances down here to cover both up and down is huge. This is a very busy area, particularly at night," Dukes said.
Dukes said the area averages about 10,000 emergency calls a year.
The units will be equipped for advanced life support, with paramedics taking care of anything short of surgery.
The city provided the property and the state contributed $3.2 million for construction.